FormerpolicedetectiveAdrianMonk(TonyShalhoub),whosephotographicmemoryandamazingabilitytopiecetogethertinycluesmadehimalocallegend,hassufferedfromintensifiedobsessive-compulsivedisorderandavarietyofphobiassincetheunsolvedmurderofhiswife,Trudy,in1997.NowonpsychiatricleavefromtheSanFranciscoPoliceDepartmentandworkingasafreelancedetective/consultantondifficultcases,Monkhopestoconvincehisformerboss,CaptainLelandStottlemeyer(TedLevine),toallowhimtoreturntotheforce.Stottlemeyer,whowaveredbetweenadmirationforMonkandannoyanceathiseccentricitiesduringthefirstseason,isbecomingmoreofafriendtoMonkastheseriesdevelops,frequentlycallinghimintohelp,asmuchforMonk’sbenefitasforhisown.However,heknowsMonk’slimitationsaswellashisstrengthsandmaystillharbordoubtsaboutthewisdomofallowingMonktocarryagunorsubdueaperpetrator.Stottlemeyer’ssecond-in-command,LieutenantRandallDisher(JasonGray-Stanford),alsoseemstobedevelopingbothadmirationandcompassionforthemanheoncelabeled"thedefectivedetective."Despiteflawsandinadequaciesallaround,thethreearebecominganincreasinglyeffectiveteam,withadditionalhelpfromMonk’spersonalassistant.Fromthedouble-episodepilotthroughthefirsthalfofseasonthree,Monkwasaidedbyhisnurse,SharonaFleming(BittySchram).Butinthetenthepisodeofthethirdseason,Sharonawasreplacedbyanewassistant,NatalieTeeger(TraylorHoward).LikeSharona,adivorceewithasonnamedBenjy,Natalieisasingleparent,awidowwithadaughternamedJulie(EmmyClarke).UnlikeSharona,Natalieisnotanursebutaformerbartenderwithafreshperspectiveon"Mr.Monk,"asshestilladdresseshernewboss.
迈克尔·法斯宾德,朱迪·特纳-史密斯,杰弗里·怀特,凯瑟琳·沃特斯顿,理查·基尔,约翰·马加罗,瑟吉·诺普科,库尔特·埃贾万,朱莉娅·威斯科特-哈顿,叶夫根尼奥斯·卡科利里斯,理查德·埃弗雷特,迈克尔·布莱特,奥列克桑德·鲁登斯基