FormerpolicedetectiveAdrianMonk(TonyShalhoub),whosephotographicmemoryandamazingabilitytopiecetogethertinycluesmadehimalocallegend,hassufferedfromintensifiedobsessive-compulsivedisorderandavarietyofphobiassincetheunsolvedmurderofhiswife,Trudy,in1997.NowonpsychiatricleavefromtheSanFranciscoPoliceDepartmentandworkingasafreelancedetective/consultantondifficultcases,Monkhopestoconvincehisformerboss,CaptainLelandStottlemeyer(TedLevine),toallowhimtoreturntotheforce.Stottlemeyer,whowaveredbetweenadmirationforMonkandannoyanceathiseccentricitiesduringthefirstseason,isbecomingmoreofafriendtoMonkastheseriesdevelops,frequentlycallinghimintohelp,asmuchforMonk’sbenefitasforhisown.However,heknowsMonk’slimitationsaswellashisstrengthsandmaystillharbordoubtsaboutthewisdomofallowingMonktocarryagunorsubdueaperpetrator.Stottlemeyer’ssecond-in-command,LieutenantRandallDisher(JasonGray-Stanford),alsoseemstobedevelopingbothadmirationandcompassionforthemanheoncelabeled"thedefectivedetective."Despiteflawsandinadequaciesallaround,thethreearebecominganincreasinglyeffectiveteam,withadditionalhelpfromMonk’spersonalassistant.Fromthedouble-episodepilotthroughthefirsthalfofseasonthree,Monkwasaidedbyhisnurse,SharonaFleming(BittySchram).Butinthetenthepisodeofthethirdseason,Sharonawasreplacedbyanewassistant,NatalieTeeger(TraylorHoward).LikeSharona,adivorceewithasonnamedBenjy,Natalieisasingleparent,awidowwithadaughternamedJulie(EmmyClarke).UnlikeSharona,Natalieisnotanursebutaformerbartenderwithafreshperspectiveon"Mr.Monk,"asshestilladdresseshernewboss.
杰丝·布什,克里斯蒂娜·钟,西莉亚·罗丝·古丁,阿德里安·霍姆斯,克里斯汀·霍恩,丹·让诺特,卡罗尔·凯恩,亚历克丝·卡普,安松·蒙特,Chris,Myers,梅利莎·纳维亚,比安卡·努加拉,基利安·奥沙利文,巴布斯·奥卢桑莫昆,帕顿·奥斯瓦尔特